Reaction #59394

Reaction equation

(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril

hydrogen chloride

→

(R)-3-amino-3,4-dihydrocarbostyril hydrochloride

Solvents

1,4-dioxane

Conditions

Workup

1. 1
   OtherThe solvent was evaporated under vacuum
2. 2
   Otherevaporated under vacuum

Procedure

(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (178 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (10 mL) at 0° C. After 1 h the solution was slowly warmed to room temperature over 2 h. The solvent was evaporated under vacuum, and the residue was twice taken up in toluene (10 mL) and evaporated under vacuum to provide (R)-3-amino-3,4-dihydrocarbostyril hydrochloride, a white solid (132 mg).

Source