Reaction #592255
ord-e290cce8ef914ea8a3ff203da847e888
Reaction equation
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide
sodium trimethylsilanolate
→
title compound
Yield 27.0%
6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid
Yield 27.0%
Reactants
Reagents
None
Solvents
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1Concentrationthe mixture was concentrated in vacuo
- 2Otherpurified by prep
Procedure
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.