Reaction #5898

Reaction equation

7-amino-[5H]indeno[1,2-c]pyridazin-3(2H)-one hydrochloride

4H-pyran-4-one

ammonia

→

title compound

7-(4-Oxo-1,4-dihydropyridin-1-yl)-[5H]indeno[1,2-c]pyridazin-3(2H)-one

Solvents

water

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperatureunder reflux for 1 hour in a nitrogen atmosphere
3. 3
   Otherto give a solid, 0.9 g, m.p. >300° C
4. 4
   OtherThis solid was triturated
5. 5
   Temperaturewith warm dilute hydrochloric acid
6. 6
   Washwashed with water

Procedure

A stirred mixture of 7-amino-[5H]indeno[1,2-c]pyridazin-3(2H)-one hydrochloride (1.0 g) and 4H-pyran-4-one (0.48 g) in water (10 ml) was heated under reflux for 1 hour in a nitrogen atmosphere. The warm mixture was neutralised with aqueous ammonia to give a solid, 0.9 g, m.p. >300° C. This solid was triturated with warm dilute hydrochloric acid and washed with water to give the title compound, 0.42 g, m.p. >300° C.

Source