Reaction #587763

Reaction equation

dibenzofuran

trioxane

bromide

→

bromide

2-Bromomethyl-dibenzofuran

Solvents

acetic acid

HBr

Conditions

Workup

1. 1
   Concentrationconcentrated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in CH2Cl2
3. 3
   Washwashed with water
4. 4
   Dryingdried over Na2SO4
5. 5
   Otherevaporated

Procedure

A mixture of dibenzofuran (93.5 g, 0.557 M), trioxane (20 g, 0.222 M) and myrystyltrimethylammonium bromide (6.2 g, 18.5 mmol) in 1 L acetic acid and 135 mL of 48% HBr was stirred at 50-60° C. for 28 h, then concentrated; the residue was dissolved in CH2Cl2, washed with water, dried over Na2SO4, evaporated to give the crude bromide 1a. Compound 1a was used without further purification in the next step.

Source