Reaction #586150

Reaction equation

4-ethoxy-3-methyl-1,1,1-trifluoro-3-buten-2-on

hydrazine hydrate

→

4-methyl-3-trifluoromethylpyrazol

Yield 86.7%

Solvents

ethanol

Conditions

Workup

1. 1
   workup.DISTILLATIONThe ethanol was distilled off under reduced pressure
2. 2
   Otherthe residue was separated with ethyl acetate and water
3. 3
   WashThe organic layer was washed with water twice
4. 4
   Dryingdried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedure

1.7 g (10.2 mmol) of 4-ethoxy-3-methyl-1,1,1-trifluoro-3-buten-2-on and 0.6 g (12.0 mmol) hydrazine hydrate were stirred in 50 ml of ethanol at room temperature for 2 hours. The ethanol was distilled off under reduced pressure, and the residue was separated with ethyl acetate and water. The organic layer was washed with water twice and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 1.3 g of 4-methyl-3-trifluoromethylpyrazol (yield 86.7%).

Source