Reaction #58294

ord-919f3b533e4a42edb8eb1acaf06fb298

Reaction equation

COc1ccc(Br)c(C(=O)O)c1
2-bromo-5-methoxybenzoic acid
[Li][CH2]CCC
n-butyllithium
CON(C)C(C)=O
N-methoxy-N-methylacetamide
→
COc1ccc(C(C)=O)c(C(=O)O)c1
2-acetyl-5-methoxybenzoic acid

Reactants

COc1ccc(Br)c(C(=O)O)c1
2-bromo-5-methoxybenzoic acid
[Li][CH2]CCC
n-butyllithium
CON(C)C(C)=O
N-methoxy-N-methylacetamide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThis compound is synthesized
  2. 2
    Otherin the following reaction

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-N-methylacetamide. It is used in crude form in the following reaction.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07423030B2uspto-grants-2008_09