Reaction #57819

Reaction equation

rac-2,2′-bis (diphenylphosphino)-1,1′-binaphthyl

4-Bromo-N-[4,5-difluoro-2-(pyridine-3 -carbonyl)-phenyl]-benzenesulfonamide

potassium phosphate tribasic monohydrate

morpholine

→

title compound

N-[4, 5-Difluoro-2-(pyridine-3-carbonyl)-phenyl]-4-morpholin-4-yl-benzenesulfonamide

Solvents

DMF

Conditions

Workup

1. 1
   OtherThe title compound was prepared
2. 2
   OtherHPLC purification

Procedure

The title compound was prepared according to the general procedure for the synthesis of heterocyclyl and heteroaryl substituted phenylsulfonyl derivatives previously described, using 4-Bromo-N-[4,5-difluoro-2-(pyridine-3 -carbonyl)-phenyl]-benzenesulfonamide 0.2 g (0.44 mmol), potassium phosphate tribasic monohydrate 0.607 g (2.64 mmol), rac-2,2′-bis (diphenylphosphino)-1,1′-binaphthyl 0.082 g (0.06 mmol), morpholine 0.30 g (2.2 mmol) and Pd (dba)3 0.06 g (0.06 mmol) in 2 ml DMF. HPLC purification gave yellow title compound.

Source