Reaction #57280

ord-f5c2cc566f844412b155ea8fa78f11fa

Reaction equation

Clc1ncc(Br)cn1
5-bromo-2-chloropyrimidine
CN1CCNCC1
N-methylpiperazine
→
CN1CCN(c2ncc(Br)cn2)CC1
title compound
CN1CCN(c2ncc(Br)cn2)CC1
5-bromo-2-(4-methyl-1-piperazinyl)pyrimidine

Reactants

—
Intermediate 234
Clc1ncc(Br)cn1
5-bromo-2-chloropyrimidine
CN1CCNCC1
N-methylpiperazine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Following the procedure described for Intermediate 234 using 5-bromo-2-chloropyrimidine and N-methylpiperazine provided the title compound. ESMS [M+H]+: 257.0/259.0.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419988B2uspto-grants-2008_09