Reaction #56930

Reaction equation

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol

bromomethyl-cyclohexane

→

4-chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine

Yield 20.0%

Conditions

Procedure

Following the method described in Example 72, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol and bromomethyl-cyclohexane provided 4-chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine (20% yield).

Source