Reaction #56912

Reaction equation

4-chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine

4,6-dichloro-pyrimidin-2-yl-amine

5-bromo-2-methoxy-phenyl boronic acid

→

4-chloro-6-(5-bromo-2-methoxy-phenyl)-pyrimidin-2-yl-amine

Yield 53.0%

Conditions

Procedure

Following the method described in Example 4 for the synthesis of 4-chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine, 4,6-dichloro-pyrimidin-2-yl-amine and 5-bromo-2-methoxy-phenyl boronic acid provided 4-chloro-6-(5-bromo-2-methoxy-phenyl)-pyrimidin-2-yl-amine (53% yield).

Source