Reaction #5619

Reaction equation

1-methyl-4-(4-hydroxy-5-benzyloxy-2-pyridylcarbonyl)piperazine

→

1-methyl-4-(4,5-dihydroxy-2-pyridylcarbonyl)piperazine

Yield 38.7%

Solvents

methanol

Conditions

Workup

1. 1
   OtherAfter the catalyst was removed by filtration
2. 2
   Otherthe filtrate was evaporated to dryness

Procedure

To a solution of 1-methyl-4-(4-hydroxy-5-benzyloxy-2-pyridylcarbonyl)piperazine (4.71 g) in methanol (300 ml) was added 10 palladium-carbon (2.35 g) in a stream of nitrogen and the mixture was hydrogenated at atmospheric pressure for 20 minutes. After the catalyst was removed by filtration, the filtrate was evaporated to dryness. The residue was recyrstallized from methanol to give 1-methyl-4-(4,5-dihydroxy-2-pyridylcarbonyl)piperazine (1.32 g).

Source