Reaction #5610

Reaction equation

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

Solvents

tetrahydrofuran

diisopropyl ether

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperaturerefluxed for an hour
3. 3
   TemperatureThe mixture was cooled
4. 4
   Filtrationthe resulting precipitate was collected by filtration
5. 5
   Washwashed with diisopropyl ether
6. 6
   Otherair-dried at ambient temperature

Procedure

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

Source