Reaction #55621

Reaction equation

4-amino-2,6-dimethoxypyrimidin

2-chlorobenzenesulfonylisocyanate

→

N-[(2,6-dimethoxypyrimidin-4-yl)aminocarbonyl]-2-chlorobenzenesulfonamide

Solvents

methylene chloride

Conditions

Workup

1. 1
   Temperaturerefluxed an additional 15 minutes
2. 2
   OtherVolatiles were removed under reduced pressure
3. 3
   Otherthe solid thereby obtained
4. 4
   Washwas washed with a little diethyl ether

Procedure

To a mixture of 1.10 g of 4-amino-2,6-dimethoxypyrimidin in 40 ml methylene chloride at ambient temperature and pressure was added 1.60 g of 2-chlorobenzenesulfonylisocyanate. The reaction was stirred 30 minutes and then refluxed an additional 15 minutes. Volatiles were removed under reduced pressure and the solid thereby obtained was washed with a little diethyl ether; yield 2.30 g, m.p. 193°-196°.

Source