Reaction #55620

Reaction equation

4-amino-2,6-dimethoxypyrimidine

2-methylbenzenesulfonylisocyanate

→

N-[(2,6-dimethoxypyrimidin-4-yl)aminocarbonyl]-2-methylbenzenesulfonamide

Solvents

methylene chloride

Conditions

Workup

1. 1
   Filtrationfiltered
2. 2
   Otherthe solid thereby obtained
3. 3
   Washwas washed with a small amount of acetonitrile

Procedure

To a stirred mixture of 2.40 g of 4-amino-2,6-dimethoxypyrimidine in 40 ml methylene chloride at ambient temperature and pressure was slowly added 3.0 g of 2-methylbenzenesulfonylisocyanate. The reaction was stirred 40 minutes, filtered, and the solid thereby obtained was washed with a small amount of acetonitrile; yield 4.0 g, m.p. 174°-175°, NMR (DMSO-d6) relative to tetramethylsilane: δ 2.77, S, area 30; δ 4.05, S, area 60; δ 6.85, S, area 89; δ 7.7-8.6, multiplets, area 45; δ 10.00, S, area 9.

Source