Reaction #554871

ord-214cec027c594f3fa5c8837fe74c5428

Reaction equation

CC1(C)CCNC1
3,3-dimethyl-pyrrolidine
O=C(O)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1
3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid
CC1(C)CCN(C(=O)c2ccncc2NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)C1
title compound
Yield 34.0%
CC1(C)CCN(C(=O)c2ccncc2NC(=O)c2nc(C3CC3)ccc2Nc2cncnc2)C1
6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(3,3-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide
Yield 34.0%

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

According to the general method described in step 3 of example 53, reaction of 3,3-dimethyl-pyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (34%) as amorphous yellow solid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08623866B2uspto-grants-2014_01