Reaction #554640

Reaction equation

4-bromophenylacetone

ammonia

hydrogen

→

1-(4-Bromophenyl)propane-2-amine

Solvents

MeOH

Conditions

Workup

1. 1
   OtherAfter complete reaction
2. 2
   Filtrationthe mixture is filtrated
3. 3
   WashThe residue is washed with MeOH
4. 4
   Otherthe solvent of the filtrate is removed in vacuo
5. 5
   OtherThe crude product is used without further purification

Procedure

A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.

Source