Reaction #55456

Reaction equation

2-(1-benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one

sodium acetate

hydroxylamine hydrochloride

→

crude product

Yield 94.4%

2-(1-Benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one oxime

Yield 94.4%

Solvents

chloroform

methanol

water

Conditions

Workup

1. 1
   Washwashed with water
2. 2
   Otherdried
3. 3
   Otherevaporated

Procedure

To a solution of 2-(1-benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one (11.2 g., 0.0368 mole) in methanol (50 ml.) and water (20 ml.) is added sodium acetate (3.1 g.) and hydroxylamine hydrochloride (2.6 g., 0.037 mole). The reaction is stirred at ambient temperature for 5 hours. The mixture is diluted with chloroform, washed with water, dried and evaporated to give a solid crude product (11.1 g.), 2-(1-benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one oxime, which is used as is in the following steps.

Source