Reaction #55181

Reaction equation

3-(2',4'-difluoro-4-biphenylyl)butyric acid

H2SO4

→

3-(2',4'-difluoro-4-biphenylyl)butyric acid n-butyl ester

Solvents

n-butanol

Conditions

Workup

1. 1
   Temperatureunder reflux with 1 ml
2. 2
   OtherThe mixture is evaporated
3. 3
   Washthe chloroform solution is washed with NaHCO3 solution
4. 4
   Otherdried
5. 5
   Otherevaporated

Procedure

2 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid are heated under reflux with 1 ml. of concentrated H2SO4 and 30 ml. of n-butanol for 7 hours. The mixture is evaporated and taken up in chloroform and the chloroform solution is washed with NaHCO3 solution, dried and evaporated to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid n-butyl ester.

Source