Reaction #55097

Reaction equation

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

hydrogen bromide

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

Solvents

acetic acid

Conditions

Workup

1. 1
   Temperatureunder reflux for 7 hours
2. 2
   TemperatureCooling

Procedure

A mixture of 4-hydroxymethyl-5-methylimidazole hydrochloride (15.0 g.), cysteamine hydrochloride (11.5 g.) and a solution of hydrogen bromide in acetic acid (48%, 225 ml.) was heated under reflux for 7 hours. Cooling afforded 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (21.6 g.), m.p. 208°-211°.

Source