Reaction #550813

Reaction equation

P,P-bis(2,2-dimethyl-1-aziridinyl)thiophosphinic bromide

methylamine

→

P,P-bis(2,2-dimethyl-1-aziridinyl)-N methylthiophosphinic amide

Yield 65.0%

Solvents

THF

Conditions

Workup

1. 1
   Filtrationfiltered
2. 2
   Concentrationconcentrated on a rotary evaporator at room temperature
3. 3
   workup.DISTILLATIONvacuum distilled

Procedure

In a similar manner 0.025 moles of P,P-bis(2,2-dimethyl-1-aziridinyl)thiophosphinic bromide in about 170 milliliters of THF, prepared in accordance with Example 1, is saturated with an excess of gaseous methylamine, stirred over night at 4° C., filtered, concentrated on a rotary evaporator at room temperature, and vacuum distilled to provide about 65% yield of P,P-bis(2,2-dimethyl-1-aziridinyl)-N methylthiophosphinic amide.

Source