Reaction #548959

Reaction equation

chloropinacoline

4-methyl-1-piperazinyl-thiocarboxamide

diethyl ether

→

2-(4-methyl-1-piperazinyl)-4-tert.butyl-thiazole

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturethe mixture is heated to the boil on a water bath for 1 hour
2. 2
   TemperatureCooling
3. 3
   FiltrationThe precipitated crystals are filtered off
4. 4
   Otherrecrystallized from ethanol

Procedure

1.34 g of chloropinacoline are dissolved in 15 cc of absolute ethanol. After the addition of 1.6 g of 4-methyl-1-piperazinyl-thiocarboxamide, the mixture is heated to the boil on a water bath for 1 hour. Cooling is then effected and diethyl ether is added until the mixture remains turbid. The precipitated crystals are filtered off and recrystallized from ethanol. The resulting 2-(4-methyl-1-piperazinyl)-4-tert.butyl-thiazole hydrochloride has an M.P. of 206°. The base liberated from its hydrochloride in known manner by treatment with an aqueous sodium hydroxide solution has a B.P. of 97°-99°/0.2 mm Hg.

Source