Reaction #548356

Reaction equation

4-(4-chloro-3-chlorosulfonylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide

cyclopentylmethyl amine

triethyl amine

→

4-(4-Chloro-3-cyclopentylmethylsulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

Solvents

ethanol

Conditions

Workup

1. 1
   workup.WAITto stand over night
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   Otherthe amorphous end product was crystallized under 80 ml of water
4. 4
   Otherat 80° C

Procedure

8.8 g of 4-(4-chloro-3-chlorosulfonylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide were introduced portionswise at 20° C in a stirred mixture of 4 g of cyclopentylmethyl amine, 8 g of triethyl amine and 100 ml of ethanol and the reaction mixture was allowed to stand over night. The solvent was distilled off under reduced pressure and the amorphous end product was crystallized under 80 ml of water. Colorless solid body, decomposition beginning at 80° C, γ C=N 1620 cm-1.

Source