Reaction #54617

Reaction equation

3-methyl-4-fluoronitrobenzene

tetrahydrofurfurylamine

→

2-methyl-4-nitro-N-tetrahydrofurfurylaniline

Solvents

water

Conditions

Workup

1. 1
   OtherThe expected product rapidly crystallises
2. 2
   Filtrationafter it has been filtered off
3. 3
   Washwashed with water
4. 4
   Otherrecrystallised from ethanol
5. 5
   Otherdried in vacuo, it melts at 60° C.

Procedure

A mixture of 0.2 mol (31.0 g) of 3-methyl-4-fluoronitrobenzene and 0.7 mol (70.7 g) of tetrahydrofurfurylamine is heated for one hour in an oil bath at 140° C. The reaction mixture is then poured into 400 g of ice-cooled water. The expected product rapidly crystallises; after it has been filtered off, washed with water, recrystallised from ethanol and dried in vacuo, it melts at 60° C.

Source