Reaction #539355

Reaction equation

4-Amino-3-methyl-5-nitrobiphenyl

→

3,4-diamino-5-methylbiphenyl

Yield 100.0%

Solvents

ethanol ethyl acetate

Ethyl acetate hexane

Conditions

Workup

1. 1
   FiltrationThe mixture was filtered
2. 2
   Concentrationthe filtrate was concentrated under reduced pressure

Procedure

[step 3] 4-Amino-3-methyl-5-nitrobiphenyl (100 mg, 0.44 mmol) obtained in step 2 was dissolved in ethanol-ethyl acetate (1/1, 4 mL), and the mixture was stirred in the presence of 10% palladium carbon (10 mg) under a hydrogen atmosphere at room temperature for 20 hr. The mixture was filtered, and the filtrate was concentrated under reduced pressure to give 3,4-diamino-5-methylbiphenyl (87 mg, 100%).

Source