Reaction #53834

ord-a880bc35e718474580a8d818afe49a92

Reaction equation

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
O=S(=O)(Cl)c1ccc(F)cc1F
2,4-difluoro-benzenesulfonyl chloride
→
CN([C@H]1CC[C@H](OCCCCBr)CC1)S(=O)(=O)c1ccc(F)cc1F
trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-2,4-difluoro-N-methyl-benzenesulfonamide

Reactants

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
O=S(=O)(Cl)c1ccc(F)cc1F
2,4-difluoro-benzenesulfonyl chloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

In analogy to example 11.9, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and 2,4-difluoro-benzenesulfonyl chloride (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-2,4-difluoro-N-methyl-benzenesulfonamide which was used directly in the next steps see Example 12.57-12.58 and 12.65 and 12.66.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02