Reaction #531790

Reaction equation

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

Yield 95.7%

3-(tritylthio) propanoic acid

Yield 95.7%

Solvents

methylene chloride

Conditions

Workup

1. 1
   Otherwere carried out at room temperature
2. 2
   Filtrationwas filtered
3. 3
   Washwas rinsed with 40 ml of diethyl ether
4. 4
   OtherThe precipitate was then dried under reduced pressure

Procedure

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

Source