Reaction #53041

ord-1380240ceead4434aa5376ba4f56b55c

Reaction equation

Nc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1
(Z)-3-[1-(4-aminophenylamino)-1-phenyl-methylidene]-2-indolinone
CC(C)(C)OC(=O)NCC(=O)O
N-tert.butoxycarbonyl-glycine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt
CN1CCOCC1
N-methylmorpholine
→
CC(C)(C)OC(=O)NCC(=O)Nc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1
(Z)-3-[1-(4-tert.butoxycarbonylaminomethylcarbonylamino-phenylamino)-1-phenyl-methylidene]-2-indolinone

Reactants

Nc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1
(Z)-3-[1-(4-aminophenylamino)-1-phenyl-methylidene]-2-indolinone
CC(C)(C)OC(=O)NCC(=O)O
N-tert.butoxycarbonyl-glycine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt
CN1CCOCC1
N-methylmorpholine

Reagents

None

Solvents

CN(C)C=O
DMF

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared analogously to Example 18 from (Z)-3-[1-(4-aminophenylamino)-1-phenyl-methylidene]-2-indolinone, N-tert.butoxycarbonyl-glycine, TBTU, HOBt and N-methylmorpholine in DMF.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855710B2uspto-grants-2005_02