Reaction #52642

Reaction equation

4-anisidine

hydrochloric acid

hydroxylamine hydrochloride

chloral hydrate

sodium sulfate

→

N—(2-hydroximinoacetyl)anisidine

Yield 85.2%

Solvents

water

water

water

Conditions

Workup

1. 1
   Otherwas held at 60° C.
2. 2
   workup.ADDITIONThe first solution was then added to the second and the reaction
3. 3
   Temperaturewas refluxed for 2 minutes
4. 4
   Temperaturecooled in an ice bath
5. 5
   OtherThe tan precipitate which formed
6. 6
   Filtrationwas collected by vacuum filtration
7. 7
   Washwashed with water
8. 8
   Otherdried under vacuum

Procedure

A solution of 11.4 g of hydroxylamine hydrochloride in water (50 ml) was added to a solution of chloral hydrate (9.6 g) and sodium sulfate (83 g) in water (200 ml) at 60° C. The mixture was held at 60° C. while, in a separate flask, a solution of 4-anisidine (6.4 g) and concentrated hydrochloric acid (4.3 ml) in water (80 ml) was warmed to 80° C. The first solution was then added to the second and the reaction was refluxed for 2 minutes, cooled slowly to room temperature and then cooled in an ice bath. The tan precipitate which formed was collected by vacuum filtration, washed with water and dried under vacuum to give 8.6 g (85% yield) of N—(2-hydroximinoacetyl)anisidine.

Source