Reaction #52416

Reaction equation

[4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane

Intermediate 60

[4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane

potassium carbonate

→

1-Ethynyl-4-(1-methoxycyclopropyl)-benzene

Solvents

methanol

Conditions

Procedure

Using General Procedure E; [4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 60, 285.0 mg, 1.18 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

Source