Reaction #5225

Reaction equation

2(1H)-Oxo-quinoline-3,4-dicarboxylic acid

phosphorous oxychloride

→

4-Chloro-furo[3,4-c]quinoline-1,3-dione

Conditions

Workup

1. 1
   Temperaturewas refluxed
2. 2
   ConcentrationThe reaction mixture was concentrated in vacuo
3. 3
   workup.ADDITIONthe residue treated with ice water

Procedure

A mixture of 2(1H)-Oxo-quinoline-3,4-dicarboxylic acid (2.0 g), phosphorous oxychloride (10 mL) and 8 drops of dimethyl formamide was refluxed with stirring for 20 min. The reaction mixture was concentrated in vacuo and the residue treated with ice water to afford 4-Chloro-furo[3,4-c]quinoline-1,3-dione as a tan solid.

Source