Reaction #52223
ord-1f0d3c3ac8c7474ba821015aa76506fe
Reaction equation
Reactants
Reagents
None
Solvents
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1ConcentrationThe reaction mixture was concentrated under reduced pressure
- 2workup.ADDITIONpoured into water
- 3Extractionextracted with chloroform
- 4OtherAfter drying
- 5Otherevaporation
- 6Otherthe product was purified by prep hplc
Procedure
Methyl 1-acetyl-2,3-dihydroindol-3-one-6-carboxylate (233 mg, 1 mmol), trimethyl orthoformate (10 ml) and p-toluene sulphonic acid (20 mg) were heated under reflux for 3 h. in methanol (10 ml). The reaction mixture was concentrated under reduced pressure, poured into water and extracted with chloroform. After drying and evaporation, the product was purified by prep hplc;