Reaction #521560

Reaction equation

1-chloro-3,3-dimethyl-butan-2-one

1,2,4-triazole

potassium carbonate

→

3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one

Yield 74.0%

Solvents

acetone

Conditions

Workup

1. 1
   Temperatureto cool
2. 2
   Filtrationthe inorganic salt was filtered off
3. 3
   Concentrationthe filtrate was concentrated in vacuo
4. 4
   OtherAfter treatment with diisopropyl ether, the oily residue crystallized out
5. 5
   OtherAfter drying

Procedure

13.45 g (1 mol) of 1-chloro-3,3-dimethyl-butan-2-one, 69 g (1 mol) of 1,2,4-triazole and 140 g (1 mol) of powdered potassium carbonate were heated under reflux in 500 ml of acetone for 6 hours, while stirring. Thereafter, the mixture was allowed to cool, the inorganic salt was filtered off and the filtrate was concentrated in vacuo. After treatment with diisopropyl ether, the oily residue crystallized out. After drying, 123.6 g (74% of theory) of 3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one of melting point 63°-65° C. were obtained.

Source