Reaction #52011

Reaction equation

( 9 )

(4-{[benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl benzylcarbamate

phenethyl isocyanate

benzyl isocyanate

→

title compound

(4-{[benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino }sulfonyl)amino]methyl}cyclohexyl)methyl 2-phenylethylcarbamate

Conditions

Procedure

Following procedure to make (9), phenethyl isocyanate was substituted for benzyl isocyanate to give the title compound after purification. 1H NMR (500 MHz, DMSO-d6): δ 12.43 (s, 1H), 8.45 (s, 2H), 8.10 (s, 1H), 7.37 (d, 2H), 7.27 (t, 3H), 7.16 (m, 3H), 7.07 (t, 2H), 4.34 (s, 2H), 3.61 (d, 2H), 3.14 (m, 2H), 3.30 (water), 2.88 (d, 2H), 2.66 (t, 2H), 2.48 (DMSO), 1.62 (m, 2H), 1.52 (m, 2H), 1.32 (m, 1H), 1.26 (m, 1H), 0.63 (m, 4H).

Source