Reaction #51970

Reaction equation

4-acetamidoacetophenone

bromine

→

title compound

Yield 62.5%

N-[4-(2-bromoacetyl)phenyl]acetamide

Yield 62.5%

Solvents

1,4-dioxane diethyl ether

Conditions

Workup

1. 1
   FiltrationThe solid was collected by filtration
2. 2
   Washwashed with diethyl ether
3. 3
   Otherdried under high vacuum

Procedure

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

Source