Reaction #51738

Reaction equation

7-isopropyl-4-methyl-6-thiocyanato-benzothiazol-2-yl-amine

dithiothreitol

phosphate

→

title compound

2-Amino-7-isopropyl-4-methyl-benzothiazole-6-thiol

Solvents

EtOH

Conditions

Procedure

The title compound was prepared according to General Method 14 using 7-isopropyl-4-methyl-6-thiocyanato-benzothiazol-2-yl-amine (Example L-5; 11.5 g, 43.7 mmol), dithiothreitol (27.0 g, 175 mmol), EtOH (200 mL), and phosphate buffer (50 mL). MS (APCI): 239 (M+H).

Source