Reaction #51737

ord-cbb2200b505743f89d88f8471e6e0c7a

Reaction equation

CC(C)(C)c1cc2nc(N)sc2cc1SC#N
5-tert-butyl-6-thiocyanato-benzothiazol-2-yl-amine
O[C@H](CS)[C@H](O)CS
dithiothreitol
O=P([O-])([O-])[O-]
phosphate
→
CC(C)(C)c1cc2nc(N)sc2cc1S
title compound
CC(C)(C)c1cc2nc(N)sc2cc1S
2-Amino-5-tert-butyl-benzothiazole-6-thiol

Reactants

CC(C)(C)c1cc2nc(N)sc2cc1SC#N
5-tert-butyl-6-thiocyanato-benzothiazol-2-yl-amine
O[C@H](CS)[C@H](O)CS
dithiothreitol
O=P([O-])([O-])[O-]
phosphate

Reagents

None

Solvents

CCO
EtOH

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared according to General Method 14 using 5-tert-butyl-6-thiocyanato-benzothiazol-2-yl-amine (Example L-1; 8 g, 30 mmol), dithiothreitol (18.7 g, 121 mmol), EtOH (200 mL), and phosphate buffer (50 mL). MS (APCI): 239 (M+H).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06852711B2uspto-grants-2005_02