Reaction #51328

ord-6e4353b64d914f0d9dd8180a2a62c6ef

Reaction equation

Nc1ccc2ccccc2c1
2-aminonaphthalene
CCOC(=O)C(Br)CC
ethyl 2-bromobutyrate
→
CCOC(=O)C(CC)Nc1ccc2ccccc2c1
title compound
CCOC(=O)C(CC)Nc1ccc2ccccc2c1
2-[N-(naphth-2-yl)amino]butanoic acid ethyl ester

Reactants

Nc1ccc2ccccc2c1
2-aminonaphthalene
CCOC(=O)C(Br)CC
ethyl 2-bromobutyrate

Reagents

None

Solvents

ClC(Cl)Cl
CHCl3

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPurification

Procedure

Following General Procedure AJ above and using 2-aminonaphthalene (Aldrich) and ethyl 2-bromobutyrate (Aldrich), the title compound was prepared as a solid, m.p. 81-83° C. The reaction was monitored by silica gel tlc (Rf=0.5 in CHCl3). Purification was by chromatography (silica gel using chloroform as the eluant).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849650B2uspto-grants-2005_02