Reaction #51319

Reaction equation

3,4-dichloroaniline

iso-butyl 2-oxobutanoate

→

title compound

2-[N-(3,4-dichlorophenyl)amino]butanoic acid iso-butyl ester

Conditions

Workup

1. 1
   OtherThe reaction was monitored by tlc on silica gel (Rf=0.3 in 25% EtOAc/hexanes) and purification

Procedure

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and iso-butyl 2-oxobutanoate (prepared by following General Procedure AO above using 2-oxobutyric acid (Aldrich) and iso-butanol), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.3 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Source