Reaction #51316

Reaction equation

3,4-dichloroaniline

iso-butyl 2-oxopentanoate

→

title compound

2-[N-(3,4-dichlorophenyl)amino]pentanoic acid iso-butyl ester

Conditions

Workup

1. 1
   OtherThe reaction was monitored by tlc on silica gel (Rf=0.5 in 25% EtOAc/hexanes) and purification

Procedure

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and iso-butyl 2-oxopentanoate (prepared by following General Procedure AO above using 2-oxovaleric acid (Fluka) and iso-butanol), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.5 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Source