Reaction #51230

Reaction equation

N-(tert-butoxycarbonyl)piperazine

potassium carbonate

hydrochloric acid

butyl iodide

→

N-butylpiperazine.dihydrochloride

Solvents

dimethylformamide

Conditions

Workup

1. 1
   Otherreaction

Procedure

To a dimethylformamide (7 ml) solution containing N-(tert-butoxycarbonyl)piperazine (1.0 g) were added potassium carbonate (742 mg) and then butyl iodide (1.09 g), and the mixture was stirred at room temperature for 15 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-N-butylpiperazine. This compound was acid-treated with hydrochloric acid to obtain N-butylpiperazine.dihydrochloride.

Source