Reaction #51001

Reaction equation

4-methoxy-2-nitrophenol

→

( d )

2-amino-4-methoxyphenol

Solvents

methanol

Conditions

Workup

1. 1
   OtherThe mixture was hydrogenated in a Parr™ shaker at 30 psi until consumption of hydrogen
2. 2
   FiltrationThe mixture was filtered through Celite
3. 3
   Concentrationconcentrated

Procedure

Commercially available 4-methoxy-2-nitrophenol (1 g, 5.9 mmol), a compound of formula (C) was dissolved in 10 mL of methanol, and then 10% Pd/C was added to the mixture. The mixture was hydrogenated in a Parr™ shaker at 30 psi until consumption of hydrogen stopped. The mixture was filtered through Celite and concentrated, to yield 2-amino-4-methoxyphenol a compound of formula (d), which was used without further purification.

Source