Reaction #50985

ord-13df66561d6747b989679c3e827236b8

Reaction equation

COc1ccc(O)c(N)c1
compound 12
COc1ccc(O)c(N)c1
2-amino-4-methoxyphenol
CC(=O)Oc1ccc([N+](=O)[O-])cc1
4-nitrophenyl acetate
COc1ccc(O)c([N+](=O)[O-])c1
compound 11
COc1ccc(O)c([N+](=O)[O-])c1
4-methoxy-2-nitrophenol
CC(=O)Oc1ccc(NC(=O)CCl)cc1
4-(2-chloroacetylamino)phenyl acetate
→
CC(=O)Oc1ccc(N)cc1
Compound 55
CC(=O)Oc1ccc(N)cc1
4-aminophenyl acetate

Reactants

COc1ccc(O)c(N)c1
compound 12
COc1ccc(O)c(N)c1
2-amino-4-methoxyphenol
CC(=O)Oc1ccc([N+](=O)[O-])cc1
4-nitrophenyl acetate
COc1ccc(O)c([N+](=O)[O-])c1
compound 11
COc1ccc(O)c([N+](=O)[O-])c1
4-methoxy-2-nitrophenol
CC(=O)Oc1ccc(NC(=O)CCl)cc1
4-(2-chloroacetylamino)phenyl acetate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Compound 55 was prepared in the manner of compound 12 substituting 4-nitrophenyl acetate for compound 11 in part C-1 of Example 1. Synthesis of 4-(2-chloroacetylamino)phenyl acetate (56):

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849632B2uspto-grants-2005_02