Reaction #508328

ord-d97996f7a20d4c1ebaa0130ddc82e435

Reaction equation

O=C(O)c1cc(Br)ccc1O
5-bromosalicylic acid
COc1ccc(OC)c(N)c1
2,5-dimethoxyaniline
→
COc1ccc(OC)c(NC(=O)c2cc(Br)ccc2O)c1
title compound
Yield 39.7%
COc1ccc(OC)c(NC(=O)c2cc(Br)ccc2O)c1
5-Bromo-N-(2,5-dimethoxyphenyl)-2-hydroxybenzamide
Yield 39.7%

Reactants

O=C(O)c1cc(Br)ccc1O
5-bromosalicylic acid
COc1ccc(OC)c(N)c1
2,5-dimethoxyaniline
—
raw materials

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Using 5-bromosalicylic acid and 2,5-dimethoxyaniline as the raw materials, the same operation as the example 16 gave the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08097759B2uspto-grants-2012_01