Reaction #502147

Reaction equation

2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

pyrrolidine

→

title compound

2-(3-Chlorobenzyl)-6-oxo-4-(1-pyrrolidinyl)-1,6-dihydropyrimidine-5-carbonitrile

Conditions

Procedure

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 244 mg (3.43 mmol) of pyrrolidine to give 29 mg (27% of theory) of the title compound.

Source