Reaction #502102

Reaction equation

[4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol

hydrochloric acid

→

compound

[4-[(2-Quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol hydrochloride

Solvents

dichloromethane

isopropanol

methanol

Conditions

Workup

1. 1
   workup.ADDITIONare added to the filtrate
2. 2
   ConcentrationThe reaction mixture is then concentrated under reduced pressure
3. 3
   FiltrationThe precipitate is recovered by filtration
4. 4
   Otheroven-dried under reduced pressure

Procedure

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

Source