Reaction #502097

Reaction equation

sodium borohydride

5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

→

compound

Yield 37.3%

{5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-yl}methanol

Yield 37.3%

Solvents

methanol

Conditions

Workup

1. 1
   Otherthe solvent is then evaporated off under reduced pressure
2. 2
   OtherThe organic phase is separated
3. 3
   Dryingdried over sodium sulphate
4. 4
   Concentrationconcentrated under reduced pressure

Procedure

122 mg of sodium borohydride are added, in small portions, to 104 mg of 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours, and the solvent is then evaporated off under reduced pressure. The residue is taken up between dichloromethane and water. The organic phase is separated, dried over sodium sulphate and concentrated under reduced pressure. 39 mg of compound are obtained.

Source