Reaction #5009

ord-67807ba4f6aa49a6bfa5666d55bc49c7

Reaction equation

Cc1ccccc1CC(=O)O
o-Tolylacetic acid
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN
→
CCOC(=O)Cc1ccccc1CBr
ethyl o-bromomethylphenylacetate

Reactants

Cc1ccccc1CC(=O)O
o-Tolylacetic acid
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

o-Tolylacetic acid was brominated with NBS and AIBN as described in Example 21 to give ethyl o-bromomethylphenylacetate, and this was reacted with triethyl phosphite as described in Example 2.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242908uspto-grants-1993_09