Reaction #5008

ord-72cd4b260c0043e8aa2503a92dce1f5e

Reaction equation

COC(=O)c1cccc(C)c1
Methyl m-toluate
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN
→
COC(=O)c1cccc(CBr)c1
methyl m-bromomethylbenzoate

Reactants

COC(=O)c1cccc(C)c1
Methyl m-toluate
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Methyl m-toluate was brominated with NBS and AIBN as described in Example 21 to give methyl m-bromomethylbenzoate, and this was further reacted with triethyl phosphite as described in Example 2 without further purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242908uspto-grants-1993_09