Reaction #495245

Reaction equation

Metformin hydrochloride

metformin hydrochloride

→

Metformin

Solvents

water

Conditions

Workup

1. 1
   Otherdried in the same device
2. 2
   OtherDried granulate
3. 3
   workup.ADDITIONPre-sieved magnesium stearate is added to the obtained blend
4. 4
   Otheris obtained

Procedure

Metformin hydrochloride is screened through a 1 mm sieve. Screened metformin hydrochloride is granulated in a fluid bed granulator with a solution of povidone in demineralized water and dried in the same device. Dried granulate is screened through a 1 mm sieve. The obtained granulate, microcrystalline cellulose and ethylcellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in bin blender so that the final blend is obtained. The final blend is compressed into a bilayer tablet as disclosed in Examples 16 and 17.

Source