Reaction #495243

Reaction equation

Metformin hydrochloride

metformin hydrochloride

→

Metformin

Solvents

water

Conditions

Workup

1. 1
   Otherdried in the same device
2. 2
   workup.ADDITIONPre-sieved magnesium stearate is added to the obtained blend
3. 3
   Otheris obtained

Procedure

Metformin hydrochloride is screened through a 1 mm sieve. Screened metformin hydrochloride is granulated in a fluid bed granulator with a solution of povidone in demineralized water and dried in the same device. The dried granulate is screened through a 1 mm sieve. The obtained granulate, microcrystalline cellulose and hydroxypropylcellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained.

Source